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What is Progynon Depot ?

Progynon Depot (10mg / 1mL) Injection is a hormone that is used to compensate for the loss of estrogen that occurs during menopause or after ovaries are surgically removed. [Read More]

Uses:Hormonal Replacement
Generic Name:Estradiol Valerate
USA Brand Name:Progynon Depot
Manufacturer:Cadila Healthcare

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What is the use of progynon depot injection ?

Progynon depot Injection ( 10 mg / mL ) vials are a hormone replacement therapy ( HRT ) used to substitute for the absence of Estrogen creation by the ovaries that occurs amid menopause or following careful evaluation of the ovaries, to calm direct to extreme side effects of menopause caused by estrogen insufficiency, for example, hot flushes, night sweats, restlessness, vaginal dryness, cerebral pains, state of mind swings, absence of fixation and loss of vitality.

Progynon depot medicine is likewise are additionally used to help avoid postmenopausal bone misfortune (osteoporosis) and decrease the danger of breakage. It is utilized to mitigate the side effects of cutting-edge androgen-subordinate carcinoma prostate tumor.

Estrogen invigorates the advancement of female sexual qualities, and it is utilized as a significant aspect of transgender hormone treatment for the male to female transsexuals.

When is progynon depot prescribed ?

The estradiol cypionate and estradiol valerate types of estrogen infusion are utilized to treat hot flushes (hot flashes; sudden stable sentiments of warmth and perspiring) and additionally vaginal dryness, tingling, and consuming in ladies who are encountering menopause (change of life; the finish of month to month menstrual periods).

Be that as it may, ladies who require a solution to treat vaginal dryness, tingling, or consuming ought to think about an alternative treatment. These types of estrogen infusion are likewise now and then used to treat the manifestations of low estrogen in young ladies who don't create enough estrogen usually.

The estradiol valerate type of estrogen infusion is additionally some of the time used to alleviate the side effects of specific sorts of prostate (a male regenerative organ) malignancy.

The conjugated estrogens type of estrogen infusion is utilized to treat strange vaginal draining that a specialist has chosen caused just by an issue with the measures of specific hormones in the body. Estrogen infusion is in a class of pharmaceuticals called hormones. It works by supplanting estrogen that is typically delivered by the body.

Hormone Replacement Therapy - HRT

Progynon depot Injection 10 mg infusions contain the active fixing estradiol valerate, an engineered type of ordinarily happening estradiol, which is the primary and most dynamic type of the female sex hormone estrogen and is in charge of the improvement of feminine sexual qualities and control of the menstrual cycle.

These infusions are utilized for hormone substitution treatment (HRT) and substitute for the loss of estrogen creation by the ovaries that happens amid menopause or following careful expulsion of the ovaries.

Transgender Treatment

These infusions can be utilized as a component of a sexual orientation reassignment program for male to female transsexuals, by giving a wellspring of estradiol, a functioning type of the female hormone estrogen.

These infusions invigorate the improvement of feminine optional sexual attributes, for example, bosom advancement and furthermore actuate metabolic changes, for example, fat appropriation to rethink the general body shape.

Feminizing hormone therapy

Progynon depot Injection ( Estraval Depot Injection ) 10 mg infusions contain estradiol valerate in a sterile oil arrangement, which is a long-acting estrogen planning for intramuscular use by injection.

Progynon depot is a pro drug (or antecedent) of normal human 17ß-estradiol, the most feminizing type of the female hormone estrogen, which gives a hugely successful method for feminization when utilized as a significant aspect of a sexual orientation reassignment program for male to female transsexuals.

The injection invigorates the improvement of feminine optional sexual qualities, for example, bosom advancement and furthermore actuates metabolic changes, for example, fat dissemination to rethink the general body shape, while in the meantime Progynova abrogates the impacts of testosterone. The more straightforward course of organization given by infusion may speed the physical change by making a higher and more consistent wellspring of estrogen.

How does it work ?

Estraval Depot Injection ( Progynon Depot) 10 mg vials contain estradiol valerate, an engineered type of ordinarily happening estradiol, which is the primary and most dynamic type of the female sex hormone estrogen and is organically like the natural hormone.

Every vial contains 10 mg estradiol valerate in a sterile oil arrangement, which is a long-acting estrogen readiness for intramuscular use by infusion.

Estrogen is a steroid hormone created by the ovaries that ties to particular receptors inside estrogen-responsive cells and invigorates them to make proteins associated with delivering auxiliary sexual attributes, for example, bosom improvement and in directing the menstrual cycle.

Estrogen likewise has a few different activities in different metabolic procedures including keeping up bone mass and lipid (fat) digestion.

What does this drug contain ?

The vials contain the potent fixing estradiol valerate, an engineered type of ordinarily happening oestradiol, which is the primary and most dynamic type of the female sex hormone estrogen and is in charge of the improvement of feminine sexual attributes and direction of the menstrual cycle. Every vial additionally contains a 1ml vehicle being Peanut oil (Arachis Oil) @ Treating manifestations of menopause with this medication.

Checkout Progynon depot Estradiol Valerate Injection online (Estraval Depot Injection) 10 mg infusions contain oestradiol valerate a long-acting estrogen, used to treat manifestations of menopause caused by an absence of endogenous estrogen (created by the ovaries, for example, hot flushes, night sweats, restlessness, vaginal dryness, cerebral pains, state of mind swings, absence of focus and loss of vitality.

What are the health risks ?

Long haul HRT with this injection has related wellbeing dangers, including an expanded uncertainty of bosom disease, endometrial malignancy, stroke, and deep vein thrombosis. For ladies with a flawless uterus adding a Progestogen to an estrogen swap regimen like this medicine for something like ten days for every cycle is prescribed to lessen the danger of endometrial tumor.

How to use ?

This medicine is infused into a muscle as coordinated by your specialist, generally like clockwork. For the treatment of a prostate tumor, this medicine is usually given each 1 to about fourteen days. The measurement depends on your therapeutic condition and reaction to medication.

Just in case that you are utilizing this prescription at home, take in all planning and use directions from your therapeutic services proficient. Before using, check this item outwardly for particles or staining. On the off chance that either is available, don't use the fluid.

If put away at low temperatures, the precious stone may frame in the liquid. To break down these precious stones, warm the item to room temperature before utilize. Know how to store and dispose of medicinal supplies securely.

Utilize this pharmaceutical frequently to get the most advantage from it. To enable you to recollect, stamp your logbook with an indication of when to get your measurements.

Tell your specialist if your condition does not enhance or on the off chance that it declines.

What is the Dosage ?

Are no, for the most part, settled upon prescribed doses, or suggested sedates inside classifications. The accompanying proposals depend on three sources, yet the order of medications into "prescribed" and "less suggested," originate from "Hormone Treatment in Transsexual People" (Asscheman and Gooren 1992). Measurement proposals and notes, except if generally noted, are likewise from Asscheman and Gooren.

It is suggested that MTFs take both an enemy of androgen and a wellspring of estrogen before having an orchiectomy, and end utilizing enemies of androgens after an orchiectomy (Asscheman and Gooren). Taking just an enemy of androgen brings about the danger of genuine bone thickness misfortune, and considering the only estrogen does not necessarily bring down testosterone levels. You should utilize one medication at the prescribed dose from every class.

Note that mg is a shortening for milligrams, not to be mistaken for µg, the truncation for micrograms. A microgram is 1/1,000 of a milligram. To maintain a strategic distance from some perplexity, the condensing for micrograms isn't utilized in these tables.

Different shortened forms that have been swapped for lucidity are t.i.d., which is the Latin contraction for "three times each day," p.o., which demonstrates an oral measurement, and i.m., for intramuscular infusions.

Missed Dose

Accept the missed dosage when you recollect. In the event that it is regular time for the following scheduled dose then the missed dosage can be skipped.


Contact your family doctor if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, or vaginal bleeding.

What are progynon depot Side effects ?

Sickness/spewing, swelling, bosom delicacy, cerebral pain, or weight changes may happen. In case that any of these impacts continue or intensify, tell your specialist or drug specialist quickly.

Recognize that your specialist has recommended this medicine since he or she has decided that the advantage to you is more noteworthy than the danger of reactions. Numerous individuals utilizing this medicine don't have specific symptoms.

Tell your specialist immediately on the off chance that you have any Major reactions, including.

It have some Major side effects which are as follows

  • breast lumps
  • swelling hands/ankles/feet
  • unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding)
  • persistent nausea/vomiting
  • dark urine
  • mental/mood changes
  • increased or new vaginal irritation/itching/odor/discharge
  • severe stomach/abdominal pain
  • yellowing eyes/skin
  • increased thirst/urination

This solution may work once in a while cause significant issues from blood clusters, (for example, heart assaults, strokes, deep vein thrombosis, pneumonic embolism). Get medicinal help urgently if you have any specific symptoms, including

  • chest/jaw/left arm pain
  • unusual sweating
  • tingling/weakness/numbness in the arms/legs
  • weakness on one part of the body
  • confusion
  • slurred speech
  • coughing up blood
  • sudden vision changes (such as partial/complete blindness)
  • pain/redness/swelling of legs
  • sudden/ a severe headache
  • trouble breathing
  • sudden dizziness/fainting

An intense unfavorably susceptible response to this medication is uncommon. In any case, get medical help immediately if you see any side effects of a genuine adversely the sensitive reaction, including

  • Rash
  • severe dizziness
  • trouble breathing
  • itching/swelling (especially of the face/tongue/throat)

What are precautions need to be taken ?

How should this Injection stored ?

Store at room temperature and avoid light and moisture. Keep medication out of the reach of children and pets. Do not store in the bathroom.

Do not to flush solutions down the toilet or empty them into a deplete except if instructed to do as such. Properly dispose of this item when it is terminated or never again required. Counsel your drug specialist or local waste disposal organization.

How long should you take this medication ?

You should take Estradiol Valerate Injection (Estraval Depot Injection) injections every few weeks or as recommended by your doctor for as long as your doctor prescribes.

How many substitutes are available ?

  • Progynon depot

Frequently asked questions - FAQs

Are estradiol and estrogen the same ?

Estradiol is the most potent normal estrogen (or "estrogen") created by ovaries in the female. It is unique with another female hormone that is progesterone. It's anything but a conjugated estrogen and it, not an engineered hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol.

What can I take for estrogen dominance ?

An adjusted eating regimen, work out, a reliable way of life and less introduction to environmental contamination is the thing that works best to reestablish the normal hormone adapt and diminish estrogen strength.

Your specialist may likewise begin a progesterone treatment,exacerbates that advance bile discharge, lipotropic recipes (additional discharge estrogen from the body), the substance which deactivates harmful substances and abundance hormones to expel extra estrogen from your body.

Can I take estrogen forever ?

The length of a need for hormone treatment changes from individual to individual and the condition for which it is being dealt with for.